Discussion · Bonfire Dinteg Labs

With a symptom cluster around fatigue:

Among ever-cases (n=581), CFQ items relating to lacking in energy, feeling sleepy/drowsy, needing to rest more, and having problems with tiredness had the highest prevalences across follow-ups

And the recovery trajectories? They look pretty flat: https://www.nature.com/articles/s41598-025-24868-x/figures/3 (alt text: Mean trajectories of CFQ total score, by sex, age at time of infection, EHCP and/or learning difficulties at school. Each graph is really quite flat.)

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#SARSCoV2 #COVID #COVID19 #pandemic #LongCOVID #publicHealth #health

datum (n=1)

@datum@zeroes.ca replied · last week

A valid criticism would be that some kids will have fatigue even without new viral infections. True! From the same paper:

prevalence in CYP pre-pandemic: specifically, 21.5% for fatigue

means that 61.6% rate is really 40.1/78.5 = 51.1%, so just over 50% new onset fatigue in children and young people, after SARS-CoV-2.

To me, 51.1% is not much less worrying than 61.6%!

Another valid criticism: the immune landscape has changed since this sample: many kids have had boosters and infections

Yes true! But this is fatigue - if boosters bring the rate from 50% down to 25% or even 10% or 5% that is not enough! 👉 A 1 in 10 or 1 in 20 chance of fatigue per infection is only acceptable if the rate of infection is far below the currently expected ⚠️ 14-42 SARS-CoV-2 infections per child ⚠️ from attending pre-K to grade 12 in person at 1-3 infections/year.

https://www.nature.com/articles/s41598-025-24868-x

#SARSCoV2 #COVID #COVID19 #LongCOVID #publicHealth #health

datum (n=1)

@datum@zeroes.ca replied · last week

and before someone @ s that we need proof of damage,

Also from Nature https://www.nature.com/articles/s41467-025-65597-z last week in a matched cohort:

Blood proteomics revealed broader alterations involving oxidative stress responses and synaptic function in Cog-PASC, linked to neurodegenerative pathways

with physically measurable damage:

increased neuronal and astroglial damage-associated proteins, cortical thinning in the cingulate and insular cortices, and increased hippocampal susceptibility

the damage includes frontal cortex thinning!

MRI analysis confirmed widespread cortical thinning in the Cog-PASC group, most notably in the frontal, cingulate, insular, and parietal cortices

and in typically reserved form they conclude

These findings suggest distinct neurodegenerative processes in Cog-PASC not observed in other-PASC subtypes, even after mild COVID-19 infection

#SARSCoV2 #COVID #COVID19 #pandemic #LongCOVID #publicHealth #health

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