Another aspect of Khamenei is the "Death to America" chant which has been around since he was a child.
Khamenei frequently explained that even an a country like America exists and is likely continue existing. The part of America he wants to die is the arrogant imperialism and systematic racism applied inside and out of the country.
Khamenei's beef's were squarely with our leaders who oppressed his country and the people pulling the triggers, not avg citizens.