PRESS RELEASE Groundbreaking myalgic encephalomyelitis study identifies over 250 core genes, shared biology with long COVID, and dozens of drug repurposing opportunities The study reinforces that ME is a complex multisystemic condition with a clear genetic basis and lays the foundation for future clinical trials that could be faster to recruit and more likely to succeed Read our FAQs OXFORD, UK – 4 December 2025 – PrecisionLife today announced new findings from the most detailed genetic analysis of myalgic encephalomyelitis (ME, also known as ME/CFS) ever conducted, revealing more than 250 core genes associated with the disease, including 76 genes linked with long COVID, and uncovering dozens of drug repurposing opportunities supported by genetic biomarker tests, offering potential for faster and lower-risk routes to developing targeted treatments. The study, now available as a pre-print and submitted for peer review, applied PrecisionLife's AI-led combinatorial analytics platform to analyze genomic data from two DecodeME cohorts together with UK Biobank to confirm reproducibility of results across three independent datasets. The analysis identified 7,555 genetic variants (including the 8 identified by the recent DecodeME GWAS study ), that were consistently associated with increased disease risk in three different populations.

I'm not talking to habitual maskers here - I know you mask all the time anyway. But if you don't mask any other time of year, this is the moment - the next 45 days are the time to mask up in public spaces. Yes, I know it is awkward when other people aren't doing it, but the pain and suffering, and long term health consequences you are going to spare yourself and your family, the better holidays you are going to have, the higher chance that you won't harm a medically vulnerable or elderly family member, are worth it, no? Honestly, given an unending, immune damaging pandemic, the only sensible strategy would be to to offer OPTIONAL work from home and online school from Thanksgiving to January 15, allowing families that CAN protect themselves to stay home, and those who can't to have much smaller classes with less exposure, and obviously good air filtration and masking. We aren't going to do anything so sensible, and now we're all fucked by that. But if you can mask, if you can get your kids to mask, do it now. So you get to enjoy your life.

Facebook post from Sharon Astyk: Tomorrow, y'all are going back to work and your kids are going back to school. Meanwhile, everyone and their Grandmother has been together in groups celebrating, out shopping, flying, visiting etc... Tomorrow, a lot of contagious people will still feel fine, since Covid, Flu, Norovirus and RSV ALL have periods before you show symptoms where you are contagious. The H3N2 flu seems to be hitting people VERY hard. Tomorrow, they will spread those diseases in their classrooms and workplaces, at stores and businesses, and in holiday gatherings, and those get brought to you, and your vulnerable loved ones. Statistically speaking, you can either wear a mask and get your kids to mask, or you can stay home for December (most of us can't) or you can plan to take a week to two weeks off when you and your family are sick in December and then again in January when you are sick again.

PRESS RELEASE Groundbreaking myalgic encephalomyelitis study identifies over 250 core genes, shared biology with long COVID, and dozens of drug repurposing opportunities The study reinforces that ME is a complex multisystemic condition with a clear genetic basis and lays the foundation for future clinical trials that could be faster to recruit and more likely to succeed Read our FAQs OXFORD, UK – 4 December 2025 – PrecisionLife today announced new findings from the most detailed genetic analysis of myalgic encephalomyelitis (ME, also known as ME/CFS) ever conducted, revealing more than 250 core genes associated with the disease, including 76 genes linked with long COVID, and uncovering dozens of drug repurposing opportunities supported by genetic biomarker tests, offering potential for faster and lower-risk routes to developing targeted treatments. The study, now available as a pre-print and submitted for peer review, applied PrecisionLife's AI-led combinatorial analytics platform to analyze genomic data from two DecodeME cohorts together with UK Biobank to confirm reproducibility of results across three independent datasets. The analysis identified 7,555 genetic variants (including the 8 identified by the recent DecodeME GWAS study ), that were consistently associated with increased disease risk in three different populations.